Diisopropylethylamine → HCID 11720828, compound

Participants

Reaction Steps

To a stirred mixture of 3-cyclopropylmethanesulfonyl-2(R)-[2,2-difluoro-2-(4-fluoro-phenoxy)-1(S)-(4-fluorophenyl)ethylamino]propionic acid (0.2 g, 0.42 mmol) and 1-aminocyclopropanecarbonitrile hydrochloride (0.060 g, 0.5 mmol) in DMF (3 ml), HATU (0.16 g, 0.42 mmol) and diisopropylethylamine (0.183 ml, 1 mmol) was added. After stirring overnight at room temperature, the reaction mixture was diluted with ethyl acetate and washed with water, sat. NaHCO3 and brine. After drying over sodium sulfate, the solvent was evaporated and the residue was purified by flash chromatography, using ethyl acetate/hexanes (1/1) as eluent to give the title compound as a white solid (0.09 g, 39%). 1HNMR (DMSO-d6): δ 9.01 (1H, s), 7.47 (2H, m), 7.21 (2H, m), 7.13 (2H, m), 4.29 (1H, q), 3.74 (1H, m), 3.4 (2H, m), 3.19 (3H, m), 1.36 (2H, m), 1.10 (1H, m), 1.00 (1H, m), 0.72 (1H, m), 0.57 (2H, m), 0.30 (2H, m). LC/MS, M+1: 540.3; M−1: 538.3.

Provenance & Evidence