Hydrochloric Acid → 2(S)-[2,2-difluoro-1(S)-(4-fluorophenyl)-2-pyridin-2-ylethylamino]-4,4-dimethylpentanoic acid

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Reaction Steps

To a solution of [2,2-difluoro-1(S)-(4-fluorophenyl)-2-pyridin-2-ylethyl]-[3,3-dimethyl-1(S)-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)butyl]amine (265 mg, 0.571 mmol) in a mixture of THF (5 ml) and water (5 ml) was added 1N HCl (2 ml, 2 mmol) and the reaction mixture was stirred at room temperature for 2 h. 1N NaOH (3.6 ml, 3.6 mmol) was added and stirring was continued at room temperature for 4 h. The solvent was evaporated using rotavap and 6N HCl was added dropwise to adjust the pH to 6. The precipitates were filtered and dried to obtain 2(S)-[2,2-difluoro-1(S)-(4-fluorophenyl)-2-pyridin-2-ylethylamino]-4,4-dimethylpentanoic acid (100 mg) as a white solid which was converted to the title compound as described in Example 1, Step 12 above. LC/MS: 443.2 (M−1)−1, 445.4 (M+1)+1, 466.9 (M+Na). 1HNMR (DMSO-d6): δ 8.7 (d, 1H), 8.6 (s, 1H), 7.95 (t, 1H), 7.6 (d, 1H), 7.55 (t, 1H), 7.4 (d, 2H), 7.2 (d, 2H), 4.6 (m, 1H), 2.6 (t, 1H), 1.3 (m, 4H), 0.6 (S, 10H), 0.25 (t, 1H).

Provenance & Evidence