HuagongsheHuagongshe Chemistry Print Report · For research reference only
[1-(Cyclopropylcarbamoylhydroxymethyl)cyclopropyl]carbamic acid tert-butyl ester → 2-(1-aminocyclopropyl)-N-cyclopropyl-2-hydroxyacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [1-(Cyclopropylcarbamoylhydroxymethyl)cyclopropyl]carbamic acid tert-butyl ester | HCID 67385903 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | 2-(1-aminocyclopropyl)-N-cyclopropyl-2-hydroxyacetamide | HCID 57562096 | — |
Reaction Steps
A solution of [1-(cyclopropylcarbamoylhydroxymethyl)cyclopropyl]carbamic acid tert-butyl ester in CH2Cl2 (5 mL) and TFA (5 mL) was stirred at room temperature for 2.5 h. The reaction mixture was concentrated and chased with toluene to yield 2-(1-aminocyclopropyl)-N-cyclopropyl-2-hydroxyacetamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08013183B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-52f96089a75549af8ac930f20452d90b |
| Source note | uspto-grants-2011_09 |