Dichloromethane → HCID 178470922, compound

HRID 907782Notes

Reaction equation

HRID 907782 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][O:5][C:6]2=[O:11].[CH2:12]([O:14][CH:15]([O:24][CH3:25])[C:16]1[CH:23]=[CH:22][C:19]([CH:20]=O)=[CH:18][CH:17]=1)[CH3:13].S([O-])([O-])(=O)=O.[Mg+2].Cl[CH2:33]Cl>>[CH2:12]([O:14][CH:15]([O:24][CH2:25][CH3:33])[C:16]1[CH:23]=[CH:22][C:19](/[CH:20]=[N:1]/[C:2]2[CH:10]=[CH:9][CH:8]=[C:7]3[C:3]=2[CH2:4][O:5][C:6]3=[O:11])=[CH:18][CH:17]=1)[CH3:13]

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 24083Sulfuric acid magnesium salt (1:1)HCID 122846494-Amino-1,3-dihydro-2-benzofuran-1-oneHCID 866390244-(Ethoxy(methoxy)methyl)benzaldehyde

Product 1

HCID 178470922HCID 178470922, compound

Procedure

4-Aminoisobenzofuran-1(3H)-one (600 mg, 4 mmol), 4-(ethoxy(methoxy)methyl)benzaldehyde (1.6 g, 8 mmol) and 1 g of magnesium sulfate were added into 40 mL of dichloromethane and stirred under reflux overnight, then the mixture was evaporated under reduced pressure and the residue was dried in vacuum to give 600 mg of crude product (E)-4-(4-(diethoxymethyl)benzylideneamino)isobenzofuran-1(3H)-one which without further purification was used in next step.

Workup

  1. temperatureunder reflux overnight
  2. customthe mixture was evaporated under reduced pressure
  3. customthe residue was dried in vacuum

Sources & evidence

ORD record
ord-8092775f67c2437e8af9d996bc631153
Source dataset
uspto-grants-2011_09
Patent number
US08012976B2

Reaction notes

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