HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 908028Generated: October 30, 2026
Sulfuric acid magnesium salt (1:1) → HCID 178480145, compound
https://huagongshe.com/reaction/908028
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| Reactant | 4-Amino-1,3-dihydro-2-benzofuran-1-one | HCID 12284649 | — |
| Reactant | 4-(1-Methylpyrrolidin-2-yl)benzaldehyde | HCID 86639041 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 178480145 | HCID 178480145 | 41% |
Reaction Steps
A mixture of 4-(1-methylpyrrolidin-2-yl)benzaldehyde (1.89 g, 10 mmol), 4-aminoisobenzofuran-1(3H)-one (1.49 g, 10 mmol) and MgSO4 (12 g, 100 mmol) in CH3CN (60 mL) was refluxed at 120° C. for 4 days. After a hot filtration, CH3CN was partially removed under reduced pressure and a white precipitate was appeared, the title compound was obtained by a direct filtration (1.3 g, yield 41%) as a white solid. LC-MS (ESI) m/z: 440 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08012976B2 |
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| Source dataset | uspto-grants-2011_09 |
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| ORD ID | ord-d17ccce2838842b796b11b97bc122a9a |
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| Source note | uspto-grants-2011_09 |
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