反应详情

The mixture of 1-benzyl-1H-imidazole-2-carbaldehyde (430 mg, 1.48 mmol), 4-aminoisobenzofuran-1(3H)-one (221 mg, 1.48 mmol) and magnesium sulfate (4.3 g) in acetonitrile was heated to reflux for 48 hr. Then the mixture was filtrated off and evaporated to remove the solvent. The crude was re-crystallized from isopropanol to obtain the title compound (470 mg, 65%). LC-MS (ESI) m/z: 318 (M+1)+.

1. temperaturewas heated
2. temperatureto reflux for 48 hr
3. filtrationThen the mixture was filtrated off
4. customevaporated
5. customto remove the solvent
6. customThe crude was re-crystallized from isopropanol