HRID908080

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)c1ccc([S+](c2ccccc2)c2ccccc2)cc1.[Br-]

HCID22625536

(4-tert-Butylphenyl)(diphenyl)sulfanium bromide

C22H23BrS

结构：O=C(OCC(F)(F)S(=O)(=O)[O-])C12CC3CC(CC(C3)C1)C2.[Na+]

HCID57872247

Sodium 2-(1-adamantanecarbonyloxy)-1,1-difluoroethanesulfonate

C13H17F2NaO5S

PRODUCTS

生成物

结构：CC(C)(C)c1ccc([S+](c2ccccc2)c2ccccc2)cc1.O=C(OCC(F)(F)S(=O)(=O)[O-])C12CC3CC(CC(C3)C1)C2

HCID86632755

未命名化合物

收率 86%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

In 100 g of dichloromethane were dissolved 10 g (0.02 mole) of sodium 2-(1-adamantanecarbonyloxy)-1,1-difluoroethanesulfonate (purity 70%) and 80 g (0.02 mole) of a 4-tert-butylphenyldiphenylsulfonium bromide aqueous solution. The organic layer was separated, washed three times with 20 g of water, and concentrated. Diethyl ether was added to the residue for recrystallization, obtaining the target compound as white crystals. 11 g (yield 86%).

WORKUP

后处理

customThe organic layer was separated
washwashed three times with 20 g of water
concentrationconcentrated
additionDiethyl ether was added to the residue for recrystallization

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4ee04d0ac0cc4e83a3a548e61ddb6b4e
来源数据集: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08017302B2
来源说明: uspto-grants-2011_09

反应 SMILES

[C:1]12([C:11]([O:13][CH2:14][C:15]([F:21])([F:20])[S:16]([O-:19])(=[O:18])=[O:17])=[O:12])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[Na+].[Br-].[C:24]([C:28]1[CH:33]=[CH:32][C:31]([S+:34]([C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=2)[C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)=[CH:30][CH:29]=1)([CH3:27])([CH3:26])[CH3:25]>ClCCl>[C:1]12([C:11]([O:13][CH2:14][C:15]([F:21])([F:20])[S:16]([O-:19])(=[O:17])=[O:18])=[O:12])[CH2:10][CH:5]3[CH2:4][CH:3]([CH2:9][CH:7]([CH2:6]3)[CH2:8]1)[CH2:2]2.[C:24]([C:28]1[CH:33]=[CH:32][C:31]([S+:34]([C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=2)[C:35]2[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=2)=[CH:30][CH:29]=1)([CH3:27])([CH3:25])[CH3:26]