Hydrochloric Acid → HCID 16750549, compound

Participants

Reaction Steps

1.50 g (6.24 mmol) 2-Cyano-N-ethyl-3-methoxy-benzenesulfonamide were added to a solution of 2.59 g (18.7 mmol) potassium carbonate in a mixture of 15 ml 1,4 dioxane and 6 ml of water. The solution was stirred for 24 h at room temperature. The solution was neutralized by addition of 10% HCl (pH=7). The solution was extracted twice with ethyl acetate. The organic layers were dried over Na2SO4 and concentrated. The crude product which still contained starting material was dissolved in a mixture of ethyl acetate and 10% HCl and vigorously shaken. The layers were separated and the aqueous layer was neutralized by addition of sodium bicarbonate. The aqueous layer was extracted twice with ethyl acetate. The organic layers were dried over Na2SO4 and concentrated to yield 830 mg (3.45 mmol) of the title compound having a melting point (Tmp) of 111-114° C.

Provenance & Evidence