Isopropylamine → HCID 178456968, compound

Participants

Reaction Conditions

Reaction Steps

400 mg (1.5 mmol) 3-Chloro-4-difluoromethoxy-benzo[d]isothiazole 1,1-dioxide were dissolved in 5 ml dry THF and cooled to 0° C. 883 mg (15.0 mmol) isopropylamine was dissolved in 5 ml dry THF and added slowly. Stirring was continued for 1 h at this temperature and for 14 h at room temperature. The mixture was concentrated in vacuum. The residue was purified on silica (eluent: cyclohexane/ethyl acetate 4:1) to afford 140 mg (0.48 mmol; 32% of theory) of the title compound (C.26).

Provenance & Evidence