反应详情

2-Methoxy-5-(2-oxo-propyl)-benzenesulfonamide (S. Sakurai et al. Chem. Pharm. Bull. 40(6) 1443-1451 (1992)) (0.3 g, 1.23 mmol), pyrazin-2-yl-thiourea (0.19 g, 1.23 mmol), iodine (0.31 g, 1.23 mmol) in pyridine (2.5 ml) is stirred at 60° C. for 20 hours. The mixture is concentrated. To the residue is added water, the precipitate is collected and recrystallised from ethanol to give the titled compound (0.103 g). m.p. 378.2° C.

1. concentrationThe mixture is concentrated
2. additionTo the residue is added water
3. customthe precipitate is collected
4. customrecrystallised from ethanol