Bromine → 4-(1-Bromo-2-oxo-propyl)-2-chloro-benzenesulfonamide

HRID 908150Notes

Reaction equation

HRID 908150 reaction equation
[Br:1]Br.[Cl:3][C:4]1[CH:9]=[C:8]([CH2:10][C:11](=[O:13])[CH3:12])[CH:7]=[CH:6][C:5]=1[S:14]([NH2:17])(=[O:16])=[O:15]>O1CCOCC1>[Br:1][CH:10]([C:8]1[CH:7]=[CH:6][C:5]([S:14]([NH2:17])(=[O:16])=[O:15])=[C:4]([Cl:3])[CH:9]=1)[C:11](=[O:13])[CH3:12]

Participants

4

Reactant 2

HCID 24408BromineHCID 673917572-Chloro-4-(2-oxo-propyl)-benzenesulfonamide

Product 1

HCID 859968284-(1-Bromo-2-oxo-propyl)-2-chloro-benzenesulfonamideYield 145.8%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Bromine 0.022 ml, 0.42 mmol) is added to a stirred solution of ketone (23c) (0.15 g, 6.1 mmol) in dioxan (15 ml). After 30 minutes the solvent is removed to give a brown oil (0.2 g).

Workup

  1. customAfter 30 minutes the solvent is removed

Sources & evidence

ORD record
ord-f1339c3a31ee471a8acd6af331d8ef51
Source dataset
uspto-grants-2011_09
Patent number
US08017608B2

Reaction notes

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