HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Pyrazinylthiourea → [4-Methyl-5-(4-methylsulfanyl-phenyl)-thiazol-2-yl]-pyrazin-2-yl-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Pyrazinylthiourea | HCID 2771013 | — |
| Reactant | 4-[4-Methyl-2-(pyrazin-2-ylamino)-thiazol-5-yl]-benzenesulfonamide | HCID 9928244 | — |
| Reactant | 1-[4-(Methylsulfanyl)phenyl]propan-2-one | HCID 13457708 | — |
| Product | [4-Methyl-5-(4-methylsulfanyl-phenyl)-thiazol-2-yl]-pyrazin-2-yl-amine | HCID 86761401 | — |
Reaction Steps
Using 1-(4-methylsulfanyl-phenyl)-propan-2-one (27b) and pyrazin-2-yl-thiourea (1a) in an analogous procedure described for the preparation of 4-[4-methyl-2-(pyrazin-2-ylamino)-thiazol-5-yl]-benzenesulfonamide (Example 1b) affords the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08017608B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-ed82468d7a0d4038958b8e9bc35da95d |
| Source note | uspto-grants-2011_09 |