反应详情

Oxone (Potassium peroxymonosulfate) (0.417 g, 0.77 mmol) is added to a stirred solution of [4-methyl-5-(4-methylsulfanyl-phenyl)-thiazol-2-yl]-pyrazin-2-yl-amine (27c) (0.05 g, 0.16 mmol) in acetone-water (9:1). After 2 hours at room temperature the solid precipitate is removed by filtration. The solid is dissolved in methanol, filtered to remove oxone and the solvent is removed from the filtrate to afford the title compound as a yellow solid (0.022 g).

1. customAfter 2 hours at room temperature the solid precipitate is removed by filtration
2. dissolutionThe solid is dissolved in methanol
3. filtrationfiltered
4. customto remove oxone
5. customthe solvent is removed from the filtrate