4-(Methylthio)benzaldehyde → [5-(3-Chloro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-pyridin-3-yl-amine

Participants

Role	Name	HCID	Charge
Reactant	4-(Methylthio)benzaldehyde	HCID 76985	—
Reactant	3-Pyridylthiourea	HCID 2760515	—
Reactant	3-Chloro-4-methanesulfonyl-benzaldehyde	HCID 11736115	—
Reactant	[4-Methyl-5-(4-methylsulfanyl-phenyl)-thiazol-2-yl]-pyrazin-2-yl-amine	HCID 86761401	—
Product	[5-(3-Chloro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-pyridin-3-yl-amine	HCID 86606212	—

Reaction Steps

The title compound is prepared starting from 3-chloro-4-methanesulfonyl-benzaldehyde (prepared as described in WO 01/49660 A1) and 3-pyridylthiourea following an analogous sequence of reactions described for the preparation of [4-Methyl-5-(4-methylsulfanyl-phenyl)-thiazol-2-yl]-pyrazin-2-yl-amine (27c) from 4-methylsulfanyl-benzaldehyde.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08017608B2
Source dataset	uspto-grants-2011_09
ORD ID	ord-5ee7a626977742408330c59e93a7a080
Source note	uspto-grants-2011_09