4-Chlorobenzaldehyde → 4-(Methylsulfonyl)benzaldehyde

Participants

Reaction Conditions

Reaction Steps

4-Chlorobenzaldehyde (5.0 g, 36 mmol) and methanesulfinic acid sodium salt (4.04 g, 40 mmol) are dissolved in dry DMSO under argon. The stirred reaction mixture is heated at 100° C. for 17 hours then poured onto water (50 ml). The white precipitate is removed by filtration and dried under vacuum to afford the title compound (2.2 g).

Provenance & Evidence