Ethanolamine → HCID 86606219, compound

Participants

Reaction Steps

3-[4-Methyl-2-(pyrazin-2-ylamino)-thiazol-5-yl]-benzenesulfonyl chloride (42c) (0.251 g, 0.68 mmol) is dissolved in dioxane (10 ml). The solution is treated with 2M aqueous sodium carbonate (0.7 ml, 1.36 mmol) followed by the addition of ethanolamine (0.125 ml, 2.05 mmol). The reaction mixture is stirred overnight. The solvent is removed in vacuo and the residue is taken into water (10 ml)/ethylacetate (30 ml) and sonicated. The layers are separated then the aqueous layer is extracted with ethyl acetate (2×30 ml). The combined organic layers are dried over MgSO4, filtered and concentrated to give a residue which is purified by prep LC-MS to give the titled compound (0.038 g, 14%)

Provenance & Evidence