2-Chloro-N-(2-hydroxy-ethyl)-5-(2-oxo-propyl)-benzenesulfonamide → N-(2-Hydroxy-ethyl)-3-(2-oxo-propyl)-benzenesulfonamide

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Reaction Steps

2-Chloro-N-(2-hydroxy-ethyl)-5-(2-oxo-propyl)-benzenesulfonamide (43b) (1.22 g, 4.18 mmol) in methanol (150 ml) is stirred under an atmosphere of hydrogen in the presence of 10% Palladium on carbon (1 g) for 5 hours at room temperature. Filtration through celite and removal of the solvent affords the titled compound which is purified by chromatography on silica eluting with ethyl acetate-hexane (2:1).

Provenance & Evidence