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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 908181Generated: November 1, 2026

Thiazole → HCID 178433123, compound

https://huagongshe.com/reaction/908181

Reaction equation

Participants

RoleNameHCIDCharge
ReactantThiazoleHCID 9256—
Reactant2-Chloro-N-(2-hydroxy-ethyl)-5-(2-oxo-propyl)-benzenesulfonamideHCID 67390996—
Reactant2-Chloro-5-(2-oxo-propyl)-benzenesulfonamideHCID 67392313—
Reactant2-Chloro-5-[4-methyl-2-(pyrazin-2-ylamino)-thiazol-5-yl]-benzenesulfonamideHCID 86606216—
ReactantHCID 178514162HCID 178514162—
ProductHCID 178433123HCID 178433123—

Reaction Steps

The titled compound was prepared from N-(2-hydroxy-ethyl)-3-(2-oxo-propyl)-benzenesulfonamide (43b) following the two-step procedure (bromination, thiazole formation) described for the conversion of 2-chloro-5-(2-oxo-propyl)-benzene-sulfonamide (33a) to 2-chloro-5-[4-methyl-2-(pyrazin-2-ylamino)-thiazol-5-yl]-benzenesulfonamide (33c) replacing pyrazin-2-yl-thiourea (1a) in the final step with (1H-pyrazol-3-yl)-thiourea (35a).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08017608B2
Source datasetuspto-grants-2011_09
ORD IDord-81bae09f512e4f77a5242aca15becc2a
Source noteuspto-grants-2011_09