Ammonia → HCID 85996785, compound

HRID 908182Notes

Reaction equation

HRID 908182 reaction equation
OCC[NH:4][S:5]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([C:14]2[S:18][C:17]([NH:19][C:20]3[CH:25]=[N:24][CH:23]=[CH:22][N:21]=3)=[N:16][C:15]=2[CH3:26])[CH:9]=1)(=[O:7])=[O:6].N>>[CH3:26][C:15]1[N:16]=[C:17]([NH:19][C:20]2[CH:25]=[N:24][CH:23]=[CH:22][N:21]=2)[S:18][C:14]=1[C:10]1[CH:9]=[C:8]([S:5]([NH2:4])(=[O:6])=[O:7])[CH:13]=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 86606219HCID 86606219, compound

Product 1

HCID 85996785HCID 85996785, compound

Procedure

The titled compound is prepared by an analogous procedure to N-(2-hydroxy-ethyl)-3-[4-methyl-2-(pyrazin-2-ylamino)-thiazol-5-yl]-benzenesulfonamide (Example 42 using ammonia in place of ethanolamine in the final step.

Sources & evidence

ORD record
ord-51ad16a126654c6faba98578d915b9ed
Source dataset
uspto-grants-2011_09
Patent number
US08017608B2

Reaction notes

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