反应详情

温度

75 °C

Methane sulfinic acid sodium salt (6.65 g, 65.1 mmol) is added to a stirred solution of 4-Fluoro-3-trifluoromethyl-benzaldehyde (10.0 g, 52.1 mmol) in dry DMSO (200 ml) and the mixture is heated at 75° C. After 2 hours the reaction is allowed to cool and poured onto ice-water (300 ml). The precipitate is collected by filtration, washed with water and dissolved in dichloromethane (200 ml). The organic extract is washed with water (3×200 ml), dried over MgSO4, filtered, and the solvent is removed to give the title compound as a white solid.

1. temperatureto cool
2. additionpoured onto ice-water (300 ml)
3. filtrationThe precipitate is collected by filtration
4. washwashed with water
5. dissolutiondissolved in dichloromethane (200 ml)
6. extractionThe organic extract
7. washis washed with water (3×200 ml)
8. dry with materialdried over MgSO4
9. filtrationfiltered
10. customthe solvent is removed