Ethyl isothiocyanatoformate → HCID 86606225, compound

Participants

Reaction Conditions

Reaction Steps

Ethoxycarbonylisothiocyanate (0.346 ml, 2.96 mmol) is added dropwise to a stirred suspension of 5-(4-Methyl-piperazin-1-yl)-[1,3,4]thiadiazol-2-ylamine (63b) (0.59 g, 2.96 mmol) in acetonitrile (15 ml) and DMF (5 ml). The reaction is heated at 80° C. for 7 h followed by removal of the solvent. The residue heated in 2M aqueous NaOH (80 ml) at reflux for 30 minutes. After cooling to room temperature the solution is neutralised by addition of 6M aqueous HCl and the titled product is removed by filtration and dried under vacuum.

Provenance & Evidence