Bromine → HCID 178433133, compound

HRID 908202Notes

Reaction equation

HRID 908202 reaction equation
[Br:1]Br.[F:3][C:4]1[CH:5]=[C:6]([C:14]2[S:18][C:17]([NH:19][C:20]3[CH:24]=[CH:23][NH:22][N:21]=3)=[N:16][C:15]=2[CH3:25])[CH:7]=[CH:8][C:9]=1[S:10]([CH3:13])(=[O:12])=[O:11]>C(Cl)(Cl)Cl.CO>[Br:1][C:24]1[C:20]([NH:19][C:17]2[S:18][C:14]([C:6]3[CH:7]=[CH:8][C:9]([S:10]([CH3:13])(=[O:12])=[O:11])=[C:4]([F:3])[CH:5]=3)=[C:15]([CH3:25])[N:16]=2)=[N:21][NH:22][CH:23]=1

Participants

5

Reactant 2

HCID 24408BromineHCID 178433124[5-(3-Fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-(1H-pyrazol-3-yl)-amine

Product 1

HCID 178433133HCID 178433133, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6212ChloroformSolvent2×

Procedure

Bromine (0.012 ml, 0.23 mmol) in chloroform (0.5 ml) is added dropwise to a stirred solution of [5-(3-Fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-(1H-pyrazol-3-yl)-amine (69) (0.10 g, 0.23 mmol) in chloroform (1 ml) and methanol (2 ml). After stirring at room temperature for 1 hour the hydrobromide salt of the titled compound precipitates. This is removed by filtration and washed with ether.

Sources & evidence

ORD record
ord-bb72820b4fd34245954df9c37df17f23
Source dataset
uspto-grants-2011_09
Patent number
US08017608B2

Reaction notes

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