Azetidine → 4-(Azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid (5-morpholin-4-yl-2-phenyl-imidazo[1,2-c]pyrimidin-7-yl)-amide

HRID 908235Notes

Reaction equation

HRID 908235 reaction equation
[NH:1]1[CH2:4][CH2:3][CH2:2]1.[CH3:5][N:6]1[C:10]([C:11](=[O:34])[NH:12][C:13]2[N:18]=[C:17]([N:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)[N:16]3[CH:25]=[C:26]([C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)[N:27]=[C:15]3[CH:14]=2)=[C:9]([C:35](O)=[O:36])[CH:8]=[N:7]1>>[N:19]1([C:17]2[N:16]3[CH:25]=[C:26]([C:28]4[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=4)[N:27]=[C:15]3[CH:14]=[C:13]([NH:12][C:11]([C:10]3[N:6]([CH3:5])[N:7]=[CH:8][C:9]=3[C:35]([N:1]3[CH2:4][CH2:3][CH2:2]3)=[O:36])=[O:34])[N:18]=2)[CH2:20][CH2:21][O:22][CH2:23][CH2:24]1

Participants

3

Reactant 2

HCID 10422AzetidineHCID 670422821-Methyl-5-(5-morpholin-4-yl-2-phenyl-imidazo[1,2-c]pyrimidin-7-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid

Product 1

HCID 510349164-(Azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid (5-morpholin-4-yl-2-phenyl-imidazo[1,2-c]pyrimidin-7-yl)-amide

Procedure

The title compound was prepared in analogy to Example 13, Step 2, using azetidine and 1-methyl-5-(5-morpholin-4-yl-2-phenyl-imidazo[1,2-c]pyrimidin-7-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid (Example 73, Step 1). MS (m/e)=487.2 [M+H+].

Sources & evidence

ORD record
ord-125a3d073e124e04a11133b6e4ea64a9
Source dataset
uspto-grants-2011_09
Patent number
US08017604B2

Reaction notes

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