Acetyl chloride → 1H-Benzimidazole-2-methanamine, 6,7-difluoro-, hydrochloride (1:2)

Participants

Reaction Conditions

Reaction Steps

To a MeOH 144 mL solution of the product obtained in Step B (13.9 g, 48.9 mmol) was added acetyl chloride (16.6 g, 212 mmol) at room temperature. The reaction mixture (solution) was heated to 55° C. in an oil bath for 1 hr and then cooled to room temperature. Resulting suspension was cooled in an ice-water bath and the precipitate was collected by suction filtration and dried to give the title compound (12.5 g). LC/MS; m/z 184(M+H).

Provenance & Evidence