Dichloromethane → N-[6-(Isoquinolin-5-yl)naphthalen-2-yl]-4-methoxybenzamide

Participants

Reaction Steps

To a microwave vial containing 6-(4-methoxybenzamido)naphthalen-2-yl trifluoromethanesulfonate (0.100 g, 0.2 mmol), in 1,4-Dioxane (3 mL), was added isoquinolin-5-ylboronic acid (0.129 g, 0.8 mmol), Fibrecat catalyst (0.005 g, 5% by wt.), 2 M Potassium Carbonate (0.50 mL, 1 mmol). The vial was capped and placed into CEM Microwave for 10 minutes at 80° C., while supplying 50 Watts of power through power-max. The diluted the mixture [with DCM (2 mL) and water (2 mL)] was extracted with DCM (3×10 mL). The dried organics (over sodium sulfate) was filtered, and concentrated in-vacuo. The crude was purified from reverse-phase HPLC. This gave a tan colored amorphous solid, which was titled product (0.0023 g, 0.006 mmol) MS (ESI pos. ion) m/z: 405 (M+H). Calc'd Exact Mass for C27H20N2O2: 404.

Provenance & Evidence