Lithium Hydroxide → HCID 58828852, compound

Participants

Reaction Steps

To a solution of Methyl 6-(isoquinolin-5-yl)-1-naphthoate (1.4 g, 4.4 mmol) in THF (445 mL) was added 1N LiOH (89 mL) and the resulting mixture was stirred at room temperature. The mixture was concentrated down to a small aqueous volume, which was acidified to pH 5 with conc HCl. The solid was isolated by filtration, washed with a small amount of water and dried overnight under vacuum to give 1.65 g of the titled compound.

Provenance & Evidence