4-Chloroaniline → HCID 67386813, compound

Participants

Reaction Steps

6-(isoquinolin-5-yl)-1-naphthoyl chloride (0.85 g, 0.27 mmol) was suspended in CH2Cl2 (1 mL) and triethylamine (0.057 mL, 0.4 mmol) was added followed by 4-chloroaniline (33 mg, 0.26 mol). The mixture was stirred at room temperature for 2 h, 0.1 mL of DMF was added and the mixture was stirred for an additional 72 h. A solution of aqueous NaHCO3 was added and mixture was extracted with CH2Cl2. Organic phase was dried, filtered and evaporated. Residue was purified by prep plate (ethyl acetate) to give a white solid. MS (ESI pos. ion) m/z: 409 (M+H). Calc'd Exact Mass for C26H17ClN2O: 408.

Provenance & Evidence