HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminothiazole → 6-(isoquinolin-5-yl)-N-(thiazol-2-yl)-1-naphthamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 58828852 | HCID 58828852 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 6-(isoquinolin-5-yl)-N-(thiazol-2-yl)-1-naphthamide | HCID 58828889 | — |
Reaction Steps
6-(isoquinolin-5-yl)-1-naphthoic acid (55 mg, 0.18 mmol), 2-aminothiazole (24 mg, 0.23 mmol), DIPEA (0.048 mL, 0.27 mmol) and HATU (0.1 g, 0.27 mmol) were stirred in CHCl3 (1 mL) at room temperature overnight. The solid formed was filtered, rinsed with CHCl3, MeOH and dried under vacuum to give the titled compound as a solid. MS (ESI pos. ion) m/z: 382. (M+H). Calc'd Exact Mass for C23H15N3OS: 381.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08017601B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-ae68d2277459425dba88aad393badcca |
| Source note | uspto-grants-2011_09 |