Dimethyl Sulfoxide → Tert-butyl 4-(4-hydroxy-4-phenylpiperidin-1-yl)benzoate

HRID 90835Notes

Reaction equation

HRID 90835 reaction equation
[C:14]([CH3:15])([CH3:16])([CH3:17])[O:18][C:19]([c:20]1[cH:21][cH:22][c:23]([F:26])[cH:24][cH:25]1)=[O:27].[C:28](=[O:29])([O-:30])[O-:31].[CH3:34][S:35]([CH3:36])=[O:37].[CH3:38][CH2:39][O:40][CH2:41][CH3:42].[K+:32].[K+:33].[OH:1][C:2]1([c:8]2[cH:9][cH:10][cH:11][cH:12][cH:13]2)[CH2:3][CH2:4][NH:5][CH2:6][CH2:7]1>>[OH:1][C:2]1([c:8]2[cH:9][cH:10][cH:11][cH:12][cH:13]2)[CH2:3][CH2:4][N:5]([c:23]2[cH:22][cH:21][c:20]([C:19]([O:18][C:14]([CH3:15])([CH3:16])[CH3:17])=[O:27])[cH:25][cH:24]2)[CH2:6][CH2:7]1

Participants

7

Reactant 6

HCID 679Dimethyl SulfoxideHCID 813Potassium Cation2×HCID 3283Diethyl EtherHCID 19660Carbonate IonHCID 963874-Phenylpiperidin-4-olHCID 2736444Tert-butyl 4-fluorobenzoate

Product 1

HCID 22730002Tert-butyl 4-(4-hydroxy-4-phenylpiperidin-1-yl)benzoate

Sources & evidence

ORD record
ord-916b063bdbe84609bb9001612b16a662
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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