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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 908357Generated: October 25, 2026

5-Dimethylaminomethylene-6,7-dihydro-5H-benzo[1,2,5]oxadiazol-4-one → 3-(4,5-Dihydro-2-oxa-1,3,7,9-tetraaza-cyclopenta[a]naphthalen-8-ylamino)-phenol

https://huagongshe.com/reaction/908357

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Dimethylaminomethylene-6,7-dihydro-5H-benzo[1,2,5]oxadiazol-4-oneHCID 67405521—
ReactantHCID 178418735HCID 178418735—
SolventDimethylformamideHCID 6228—
Product3-(4,5-Dihydro-2-oxa-1,3,7,9-tetraaza-cyclopenta[a]naphthalen-8-ylamino)-phenolHCID 11403271—

Reaction Steps

The DMF solution of 5-dimethylaminomethylene-6,7-dihydro-5H-benzo[1,2,5]oxadiazol-4-one 0.1 g (0.00052 mol) and 3 equivalents of N-(3-hydroxy-phenyl)-guanidine was stirred at 110° C. for overnight, the final product was purified by directly injecting the DMF reaction solution into prep HPLC.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08017619B2
Source datasetuspto-grants-2011_09
ORD IDord-57a5be34e2c14092ba998626ea8640c0
Source noteuspto-grants-2011_09