HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Tetralone → 2-dimethylaminomethylene-3,4-dihydro-2H-naphthalen-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Tetralone | HCID 10724 | — |
| Reactant | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| Reactant | tert-Butoxy bis(dimethylamino)methane | HCID 79885 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 2-dimethylaminomethylene-3,4-dihydro-2H-naphthalen-1-one | HCID 54406509 | — |
Reaction Steps
A solution of 3,4-dihydro-2H-naphthalen-1-one in MeCN and 20 eq. of DMF-DMA were stirred at 90° C. overnight. Thin layer chromatography indicated there is almost no desired product, hence 1.2 equivalents of Bredereck's reagent was added, and the reaction mixture stirred at 80° C. overnight. The solvent was removed under reduced pressure and the crude material was used for the next step with no further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08017619B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-7bab3cba545448bf8ccdac32def735a2 |
| Source note | uspto-grants-2011_09 |