Potassium Carbonate → 7-(1,1-Dioxo-2h-naphtho[1,8-cd]isothiazol-2-yl)-heptanoic acid benzyloxyamide

Beteiligte Stoffe

Reaktionsschritte

In a manner analogous to that of example 1(b), 7-bromo-heptanoic acid benzyloxyamide 0.46 g, 1.5 mmol) was reacted with 1,8-naphthalenesultam (0.3 g, 1.5 mmol) in the presence of potassium carbonate (0.2 g, 1.4 mmol) to give 7-(1,1-dioxo-2H-naphtho[1,8-cd]isothiazol-2-yl)-heptanoic acid benzyloxyamide as an amorphous solid (yield 0.4 g, 62%; purified by column chromatography using silica gel and ethyl acetate:heptane=1:1 as an eluent). MS (M+H+)=439.

Herkunft & Nachweise