Hydrochloric Acid → HCID 44256443, compound

Participants

Reaction Conditions

Reaction Steps

The 3-(1,3-benzoxazol-2-yl)-5-(1H-pyrazol-4-yl)pyridin-2-amine was prepared as follows: Hydrogen chloride (16.26 ml, 4N in dioxane) was added to a stirred suspension 3-(1,3-benzoxazol-2-yl)-5-(1-tetrahydropyran-2-ylpyrazol-4-yl)pyridin-2-amine (4.7 g) dissolved in ethanol (30 ml). The resulting mixture was stirred at 25° C. for 2 hours. The reaction was evaporated under reduce pressure, adsorbed on silica gel and purified by flash chromatography on silica gel eluting with 20 to 80% methanolic ammonia (7 N) in dichloromethane. The solvent was evaporated to dryness to afford 3-(1,3-benzoxazol-2-yl)-5-(1H-pyrazol-4-yl)pyridin-2-amine (3.35 g). NMR Spectrum: (CDCl3) 7.39-7.50 (m, 2H), 7.65 (bs, 2H), 7.80 (dd, 1H), 7.84 (dd, 1H), 7.98 (bs, 1H), 8.24 (bs, 1H), 8.45 (d, 1H), 8.55 (d, 1H); Mass spectrum: M+H+ 278

Provenance & Evidence