1-Methylpiperazine → HCID 57687046, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 1-methylpiperazine (0.115 ml) was added to 2-[4-[6-amino-5-(1,3-benzoxazol-2-yl)-3-pyridyl]pyrazol-1-yl]ethyl methanesulphonate (138 mg) dissolved DMF (5 ml). The resulting solution was stirred at 100° C. for 1 hour. The mixture was adsorbed on silica gel and purified by flash chromatography on silica gel eluting with 2 to 6% methanolic ammonia (7 N) in dichloromethane. The solvent was evaporated to dryness and the solid was triturated with hot acetonitrile to afford 3-(1,3-benzoxazol-2-yl)-5-[1-[2-(4-methylpiperazin-1-yl)ethyl]pyrazol-4-yl]pyridin-2-amine (109 mg) as a solid. NMR Spectrum: (DMSOd6) 2.14 (s, 3H), 2.30 (bs, 4H), 2.44 (bs, 4H), 2.74 (t, 2H), 4.23 (s, 2H), 7.40-7.50 (m, 2H), 7.65 (bs, 2H), 7.77-7.82 (m, 1H), 7.82-7.87 (m, 1H), 7.90 (s, 1H), 8.24 (s, 1H), 8.40 (d, 1H), 8.51 (d, 1H); Mass spectrum: M+H+ 404.

Provenance & Evidence