Dichloromethane → HCID 86630151, compound

Participants

Reaction Conditions

Reaction Steps

A solution of methanesulphonyl chloride (0.577 ml) was added to 3-[4-[6-amino-5-(1,3-benzoxazol-2-yl)-3-pyridyl]pyrazol-1-yl]propan-1-ol (1.25 g, Example 29-1), triethylamine (1.559 ml) dissolved dichloromethane (20 ml) and THF (20 ml) at 0° C. The resulting suspension was stirred at 25° C. for 2 hours. The suspension was filtered and washed with water (3 time) and dried over night on reduce pressure to afford 3-[4-[6-amino-5-(1,3-benzoxazol-2-yl)-3-pyridyl]pyrazol-1-yl]propyl methanesulphonate (0.988 g). NMR Spectrum: (DMSOd6) 2.21-2.32 (m, 2H), 3.23 (s, 3H), 4.21-4.33 (m, 4H), 7.42-7.51 (m, 2H), 7.68 (bs, 2H), 7.81 (d, 1H), 7.86 (d, 1H), 7.98 (s, 1H), 8.30 (s, 1H), 8.44 (s, 1H), 8.54 (s, 1H)

Provenance & Evidence