Ammonia → HCID 57687117, compound

Participants

Reaction Steps

A solution of tert-butyl 4-[2-[4-[6-amino-5-(1,3-benzoxazol-2-yl)-3-pyridyl]pyrazol-1-yl]ethyl]piperazine-1-carboxylate (90 mg) in TFA (3 ml) was stirred at 25° C. for 1 hour. A solution 7N ammonia in methanol (20 ml) was added to the mixture and adsorbed on silica gel. The crude product was purified by flash chromatography on silica gel eluting with 2 to 8% methanolic ammonia (7 N) in dichloromethane. The solvent was evaporated to dryness to afford 3-(1,3-benzoxazol-2-yl)-5-[1-(2-piperazin-1-ylethyl)pyrazol-4-yl]pyridin-2-amine (49.0 mg). NMR Spectrum: (DMSOd6) 2.29-2.42 (m, 4H), 2.64-2.70 (m, 4H), 2.71 (t, 2H), 4.23 (t, 2H), 7.41-7.49 (m, 2H), 7.65 (bs, 2H), 7.77-7.82 (m, 1H), 7.82-7.87 (m, 1H), 7.90 (s, 1H), 8.24 (s, 1H), 8.40 (d, 1H), 8.51 (d, 1H); Mass spectrum: M+H+ 390.

Provenance & Evidence