N-bromobutanimide → HCID 67388682, compound

Participants

Reaction Conditions

Reaction Steps

1-bromopyrrolidine-2,5-dione (427 mg) was added to a stirred solution of 3-(4-fluoro-1,3-benzoxazol-2-yl)pyridin-2-amine (500 mg) dissolved in tetrahydrofuran (20 ml) over a period of 5 minutes. The resulting solution was stirred at 25° C. for 2 hours. The solvent was evaporated and the residue was washed with water and dried over P2O5 under reduced pressure to afford 5-bromo-3-(4-fluoro-1,3-benzoxazol-2-yl)pyridin-2-amine (637 mg) as a solid. Mass spectrum: M+H+ 307-309, R.T. 3.95 min.

Provenance & Evidence