HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 908460Generated: October 30, 2026
Dimethylformamide → 5-Bromo-3-(6-fluoro-1,3-benzoxazol-2-yl)pyrazin-2-amine
https://huagongshe.com/reaction/908460
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 3-(6-Fluoro-1,3-benzoxazol-2-yl)pyrazin-2-amine | HCID 67388033 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 5-Bromo-3-(6-fluoro-1,3-benzoxazol-2-yl)pyrazin-2-amine | HCID 86630147 | — |
Reaction Steps
3-(6-Fluoro-1,3-benzoxazol-2-yl)pyrazin-2-amine (300 mg) was dissolved into DMF (15 ml) at 50° C. N-bromosuccimide (325 mg) was added. The mixture was stirred at 40° C. for 2 hours. The resulting mixture was diluted with ethyl acetate (15 ml), and washed with brine (10 ml×3). The organic layer was dried and concentrated to give 5-bromo-3-(6-fluoro-1,3-benzoxazol-2-yl)pyrazin-2-amine, which was used in the next reaction without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08017611B2 |
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| Source dataset | uspto-grants-2011_09 |
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| ORD ID | ord-cf2e7f42885d4959a29579096dabe208 |
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| Source note | uspto-grants-2011_09 |
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