2-Bromoethanol → HCID 25242541, compound

Participants

Reaction Conditions

Reaction Steps

2-Bromoethanol (0.051 ml) was added to a stirred suspension of 3-(1,3-benzoxazol-2-yl)-5-[3-(methoxymethyl)-1-piperidin-4-ylpyrazol-4-yl]pyridin-2-amine] (145 mg) and potassium carbonate (124 mg) in DMF (2 ml) at 100° C. The mixture was stirred at 100° C. for 15 hours. The reaction mixture was then purified by preparative HPLC using a Waters OBD reverse-phase column (C-18, 5 microns silica, 30 mm diameter, 150 mm length, flow rate of 40 ml/minute) and decreasingly polar mixtures of water (containing 0.2% ammonium carbonate) and acetonitrile as eluent to afford the title compound as (90 mg) as a solid.

Provenance & Evidence