HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 908528Generated: October 29, 2026
Potassium Carbonate → 1-[4-Hydroxy-3-(hydroxymethyl)-1-butyl]-uracil
https://huagongshe.com/reaction/908528
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-[2-(2,2-Dimethyl-1,3-dioxan-5-yl)ethyl]uracil | HCID 57838979 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 1-[4-Hydroxy-3-(hydroxymethyl)-1-butyl]-uracil | HCID 289650 | 88% |
Reaction Steps
A mixture of compound 34 (60 g, 0.239 mol) in 1N HCl (450 mL) was heated to 110° C. for 30 min. The reaction mixture was cooled, carefully neutralized with potassium carbonate to pH=7 and concentrated under vacuum. The residue was passed through small column using 20% methanol in chloroform to give the title compound (45 g, 88%) as a thick liquid. TLC: Chloroform/Methanol, 6:4, Rf=0.2
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08017620B2 |
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| Source dataset | uspto-grants-2011_09 |
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| ORD ID | ord-aab967587c89465f8567c8afecdd70a6 |
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| Source note | uspto-grants-2011_09 |
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