HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid monohydrate → 1-(3-Bromomethyl 4-hydroxybutyl)-1H-pyrimidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| Reactant | Chloroform methanol | HCID 21584188 | — |
| Reactant | 1-(3-Bromomethyl-4-trityloxybutyl)-1H-pyrimidine-2,4-dione | HCID 59463760 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(3-Bromomethyl 4-hydroxybutyl)-1H-pyrimidine-2,4-dione | HCID 59463759 | — |
Reaction Steps
A solution of compound 37 (22 g, 0.042 mol) in methanol (100 mL) was treated with PTSA.H2O (0.80 g, 0.0042 mol) and stirred for 6 h at RT. The reaction mixture was concentrated under vacuum and the crude compound was used for next reaction (10.5 g, crude product). TLC: Chloroform/Methanol, 1:1, Rf=0.2
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08017620B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-d12c2bb14b3f4fc19f6c8a943760ace0 |
| Source note | uspto-grants-2011_09 |