HuagongsheHuagongshe Chemistry Print Report · For research reference only
Perchloric Acid → 4-Hydroxy-6-iodo-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Perchloric Acid | HCID 24247 | — |
| Reactant | tert-Butyl 4-hydroxy-6-iodo-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate | HCID 59340042 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-Hydroxy-6-iodo-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid | HCID 59340077 | — |
Reaction Steps
To a solution of tert-butyl 4-hydroxy-6-iodo-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate (4.1 g, 10 mmol) and Acetonitrile (20 ml), cooled in an ice bath, was added 70% perchloric acid (0.2 ml) and the mixture was stirred 30 sec. A yellow solid was filtered. Yield=0.5 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08017626B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-96ed0660bb1d44839166a32ad7808d49 |
| Source note | uspto-grants-2011_09 |