HuagongsheHuagongshe Chemistry Print Report · For research reference only
Glycine methyl ester hydrochloride → HCID 59340115, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Glycine methyl ester hydrochloride | HCID 122755 | — |
| Reactant | 3-Quinolinecarboxylic acid, 1,2-dihydro-1-ethyl-4-hydroxy-2-oxo-, ethyl ester | HCID 54680568 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 59340115 | HCID 59340115 | 11% |
Reaction Steps
In 4 mL of toluene in a microwave vial, ethyl 1-ethyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylate (0.380 g, 1 mmol), glycine methyl ester hydrochloride (0.5 g, 4 mmol) was microwaved at 180° C. for 3 minutes and then purified by silica flash chromatography (with a 1-5% MeOH/DCM gradient to afford 0.050 g. Yield: 11%
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08017626B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-fd51ee0ba67d48d0a84cc163ed171212 |
| Source note | uspto-grants-2011_09 |