反应详情

温度

70 °C

To a 10 ml reaction vial was charged ethyl 2-(4-hydroxy-1-methyl-2-oxo-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-dihydroquinoline-3-carboxamido)acetate (200 mg, 465 μmol) in 1,4-dioxane (5 ml), 4,6-dichloropyrimidine (69 mg, 465 μmol), tetrakis(triphenylphosphine) palladium(0) (27 mg, 23 μmol) and sodium carbonate (0.7 ml, 1395 μmol), and the reaction vial was heated to 70° C. After reaction was complete, the reaction mixture was concentrated on a roto-evaporator, extracted with EtOAc, washed with water and brine (3× ea.) then dried with MgSO4 and concentrated on a roto-evaporator. The yellow solid was washed with EtOH and filtered and the solid was washed with ether. Yield=55 mg.

1. customTo a 10 ml reaction
2. customthe reaction
3. customAfter reaction
4. concentrationthe reaction mixture was concentrated on a roto-evaporator
5. extractionextracted with EtOAc
6. washwashed with water and brine (3× ea.)
7. dry with materialthen dried with MgSO4
8. concentrationconcentrated on a roto-evaporator
9. washThe yellow solid was washed with EtOH
10. filtrationfiltered
11. washthe solid was washed with ether