反应详情

A mixture of the compound (1.00 g) obtained in Step 5 and 7.5% palladium carbon (1.0 g) in methanol (15 ml) was stirred under a hydrogen atmosphere (5 atm) at room temperature for 4 hr. The reaction mixture was filtered through celite, and concentrated under reduced pressure. 10% Palladium carbon (500 mg) and methanol (15 ml) were added again to the residue, and the mixture was stirred under a hydrogen atmosphere (5 atm) at room temperature for 6 hr. The reaction mixture was filtered through celite, and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography (3%-5% methanol/chloroform) to give the title compound (688 mg).

1. filtrationThe reaction mixture was filtered through celite
2. concentrationconcentrated under reduced pressure
3. addition10% Palladium carbon (500 mg) and methanol (15 ml) were added again to the residue
4. stirringthe mixture was stirred under a hydrogen atmosphere (5 atm) at room temperature for 6 hr
5. filtrationThe reaction mixture was filtered through celite
6. concentrationthe filtrate was concentrated under reduced pressure
7. customThe residue was purified by column chromatography (3%-5% methanol/chloroform)