反应详情

A mixed solution of cyclopropanecarboxamidine hydrochloride (0.30 g), ethyl cyanoacetate (0.27 ml) and methanol (1.5 ml) was added to 28% sodium methoxide methanol solution (2.0 ml) under ice-cooling. After heating under reflux for 1 hr, the mixture was cooled to room temperature. The reaction mixture was concentrated under reduced pressure, and the obtained residue was adjusted to pH 5 with water and acetic acid. The precipitated solid was collected by filtration, washed with water and dried to give the title compound (0.30 g).

1. temperaturecooling
2. temperatureAfter heating
3. temperatureunder reflux for 1 hr
4. concentrationThe reaction mixture was concentrated under reduced pressure
5. filtrationThe precipitated solid was collected by filtration
6. washwashed with water
7. customdried