反应详情

To a solution of the compound (796 mg) obtained in Step 5 in chloroform (8 ml) were successively added, with stirring under ice-cooling, N,N-diisopropylethylamine (234 mg) and 2,7-dichloro-5-trifluoromethyl-thiazolo[4,5-d]pyrimidine (414 mg). After stirring at room temperature for 1 hr, the mixture was partitioned by adding chloroform and water. The aqueous layer was extracted with chloroform, and the organic layer was dried over anhydrous magnesium sulfate, filtrated, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate:n-hexane=6:1-1:2) to give the title compound (912 mg).

1. temperaturecooling
2. stirringAfter stirring at room temperature for 1 hr
3. customthe mixture was partitioned
4. additionby adding chloroform and water
5. extractionThe aqueous layer was extracted with chloroform
6. dry with materialthe organic layer was dried over anhydrous magnesium sulfate
7. filtrationfiltrated
8. concentrationconcentrated under reduced pressure
9. customThe residue was purified by silica gel column chromatography (ethyl acetate:n-hexane=6:1-1:2)