反应详情

To a solution of the compound (60 mg) obtained in Step 4 in 1,4-dioxane (0.6 ml) was added 4N hydrogen chloride/1,4-dioxane solution (0.6 ml) with stirring at room temperature. After stirring at room temperature for 2 days, the reaction mixture was concentrated under reduced pressure. Toluene was added to the residue, and the mixture was concentrated again under reduced pressure to give a crude product (about 0.095 mmol) containing the title compound as a main component. The obtained crude product was directly used for the next reaction.

1. stirringAfter stirring at room temperature for 2 days
2. concentrationthe reaction mixture was concentrated under reduced pressure
3. additionToluene was added to the residue
4. concentrationthe mixture was concentrated again under reduced pressure
5. customto give a crude product (about 0.095 mmol)