反应详情

The compound (4.68 g) obtained in Step 2 was suspended in dichloromethane (160 ml), and boron tribromide (1.0M dichloromethane solution, 35 ml) was added dropwise with stirring under ice-cooling. The reaction mixture was stirred under ice-cooling for 90 min, 4N aqueous sodium hydroxide solution (26 ml) was added dropwise with stirring under ice-cooling, and the mixture was stirred at room temperature for 30 min. The precipitated solid was collected by filtration, washed with water and acetone, and dried to give the title compound (3.15 g).

1. temperaturecooling
2. stirringThe reaction mixture was stirred under ice-
3. temperaturecooling for 90 min
4. stirringwith stirring under ice-
5. temperaturecooling
6. stirringthe mixture was stirred at room temperature for 30 min
7. filtrationThe precipitated solid was collected by filtration
8. washwashed with water and acetone
9. customdried