HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 2-Amino-4-formylthiazole-5-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Methyl 2-amino-4-(hydroxymethyl)thiazole-5-carboxylate | HCID 12308572 | — |
| Catalyst | HCID 178418406 | HCID 178418406 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-Amino-4-formylthiazole-5-carboxylic acid methyl ester | HCID 59703808 | 89.9% |
Reaction Steps
To a solution of the compound (1.35 g) obtained in Step 3 in 1,4-dioxane (68 ml)/N,N-dimethylformamide (13 ml) was added manganese dioxide (3.68 g) at room temperature and the mixture was stirred at room temperature for 40 hr. The insoluble material was filtered off, and the filtrate was concentrated under reduced pressure to give the title compound (1.20 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08017612B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-b079d13d866d4fc7b21620b8185b1d05 |
| Source note | uspto-grants-2011_09 |